Inisidon / Opipramol
April 4, 2012 | 20,00 EUR | answered by Dr. med. Hendrik Bernau
Dear Sir or Madam,
Since the end of last year, I have been unable to work due to a rehabilitation measure. Diagnosis: mild depressive episode. After not tolerating various antidepressants (Cyprilax/Venlafaxine/Citalopram) (total duration of intake: 6 weeks), my specialist (psychotherapist) has now prescribed me Opipramol. I took 100 mg for 1 week (morning and noon) and now for 4 days on 150 mg (plus 50 mg in the evening). The supposed side effects were tolerable. Although the medication is supposed to have a calming and anxiety-reducing effect, I have been feeling fluctuatingly bad in the second week of intake. While the physical symptoms have decreased (except for my tinnitus noises - they have been at their peak since then), my mood has hit rock bottom again (it was better before). Did I increase the dosage too quickly? Or are these side effects that I have to accept and will soon subside?
At the same time as taking the medication, I am trying to get my own mobilization going again (jogging, gardening, meeting friends, etc.). However, all of this requires considerable effort (physically and mentally) every time, and so far has never had any lasting effect.
What can I do differently or better?
Best regards!
Dear inquirer, if I understand your question correctly, you are referring to the compatibility of the medication you have been prescribed. Opipramol belongs to the group of tricyclic antidepressants, which generally have a low potential for dependency.
One factor to consider specifically regarding this medication is the issue that a change in dosage or discontinuation of the intake can lead to a kind of reverse effect of the medication. You mentioned that you have been increasing the dosage of the medication in the last 4 days. Was this done in consultation with your specialist or did you autonomously increase the dosage?
Your question about side effects can be answered in context: a mood-enhancing effect usually occurs within the first one to three weeks at the mentioned dosage. Therefore, I recommend you to continue with the prescribed dosage. Please keep in mind: the half-life of the medication ranges between 6 and 11 hours, depending on the individual (and usually does not change even with prolonged intake!), and in the adjustment phase it can cause drowsiness.
Regarding your approach to mobilization and participation in social life, I fully support you in this. Try not to put too much pressure on yourself, lower your expectations of yourself. Even if initially going out may require some effort, engaging in activities outside or with others will have a positive effect on your depressive phases and help you actively participate in life. Consult closely with your treating doctor and also inform them about your experiences with the mentioned medication.
Regarding the tinnitus you mentioned, it is possible that your perception is also affected by the adjustment phase, especially in "bad moments". Mention your perception in your next conversation with your treating doctor, and possibly keep a record of the times when tinnitus is predominant.
If, even after the aforementioned period, you feel like you are "stuck in one place", adjusting the therapy may be an alternative.
I hope I have been able to help you. If you have any further questions, I am always available to assist.
I wish you good health.
Best regards,
Dr. med. - anonymized -
